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A unified genetic, computational and experimental framework identifies functionally relevant residues
 

Summary: A unified genetic, computational and experimental
framework identifies functionally relevant residues
of the homing endonuclease I-BmoI
Benjamin P. Kleinstiver1
, Andrew D. Fernandes1,2
, Gregory B. Gloor1
and
David R. Edgell1,
*
1
Department of Biochemistry, Schulich School of Medicine & Dentistry and
2
Department of Applied Mathematics, The University of Western Ontario, London, ON N6A 5C1, Canada
Received November 11, 2009; Revised December 18, 2009; Accepted December 20, 2009
ABSTRACT
Insight into protein structure and function is best
obtained through a synthesis of experimental, struc-
tural and bioinformatic data. Here, we outline a
framework that we call MUSE (mutual information,
unigenic evolution and structure-guided

  

Source: Aydin, Zafer - Department of Genome Sciences, University of Washington at Seattle

 

Collections: Biology and Medicine