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Summary: A Novel Method Distinguishes Between Mutation Rates and Fixation Biases in
Patterns of Single-Nucleotide Substitution
Mikhail Lipatov,1
Peter F. Arndt,2
Terence Hwa,3
Dmitri A. Petrov1
1
Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA
2
Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14195, Berlin, Germany
3
Department of Physics and Center for Theoretical Biological Physics, University of California, San Diego, 9500 Gilman Drive, La Jolla,
CA 93092-0374, USA
Received: 6 July 2004 / Accepted: 20 June 2005 [Reviewing Editor: Dr. Nicolas Galtier]
Abstract. Analysis of the genome-wide patterns of
single-nucleotide substitution reveals that the human
GC content structure is out of equilibrium. The
substitutions are decreasing the overall GC content
(GC), at the same time making its range narrower.
Investigation of single-nucleotide polymorphisms
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