Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
JOURNAL OF COMPUTATIONAL PHYSICS 132, 260275 (1997) ARTICLE NO. CP965617
 

Summary: JOURNAL OF COMPUTATIONAL PHYSICS 132, 260275 (1997)
ARTICLE NO. CP965617
Brownian Simulation of Many-Particle Binding
to a Reversible Receptor Array
Arieh L. Edelstein and Noam Agmon
Department of Physical Chemistry and the Fritz Haber Research Center, The Hebrew University, Jerusalem 91904, Israel
Received February 21, 1996; revised June 24, 1996
recordings from ionic channels in the postsynaptic mem-
brane due to receptor binding in both neuromuscular junc-The principles and practice of a many-body Brownian dynamics
algorithm of reversible binding to a static three-dimensional recep- tions [7] and the central nervous system [8, 9]. The process
tor array are presented. The mixed boundary conditions at the array begins by exocytosis of neurotransmitters from a vesicle(s)
are compared with single-particle direct propagation using a novel
in the presynaptic membrane, their diffusion in the synapticoperator discretization. The many-body aspects are checked against
gap, reversible binding to receptors (each composed ofprevious one-dimensional Brownian simulations. The long-time be-
two binding sites), and the opening of ionic channels inhavior agrees with expected analytic solutions. 1997 Academic Press
response to the binding event.
In the model under consideration, N transmitter mole-
I. INTRODUCTION cules (noninteracting point particles) are initially at one
point on the inner face of the ``ceiling'' of the simulation
Signalling between cells in a living organism is vital for box (Fig. 1). They diffuse (with a diffusion coefficient D)

  

Source: Agmon, Noam - Institute of Chemistry, Hebrew University of Jerusalem

 

Collections: Chemistry