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Activation of Monkey Locus Coeruleus Neurons Varies With Difficulty and Performance in a Target Detection Task
 

Summary: Activation of Monkey Locus Coeruleus Neurons Varies With Difficulty and
Performance in a Target Detection Task
Janusz Rajkowski,1
Henryk Majczynski,2
Edwin Clayton,1
and Gary Aston-Jones1
1
Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania
19104-6100; and 2
Nencki Institute of Experimental Biology, 02093 Warsaw, Poland
Submitted 11 July 2003; accepted in final form 10 March 2004
Rajkowski, Janusz, Henryk Majczynski, Edwin Clayton, and
Gary Aston-Jones. Activation of monkey locus coeruleus neurons
varies with difficulty and performance in a target detection task. J
Neurophysiol 92: 361371, 2004. First published March 17, 2004;
10.1152/jn.00673.2003. We previously reported that noradrenergic
neurons in the monkey locus coeruleus (LC) are activated selectively
by target stimuli in a target detection task. Here, we varied the
discrimination difficulty in this task and recorded impulse activity of
LC neurons to analyze LC responses on error trials and in relation to

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collections: Biology and Medicine