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Gene Duplication and Gene Conversion Shape the Evolution of Archaeal Chaperonins
 

Summary: Gene Duplication and Gene Conversion Shape the
Evolution of Archaeal Chaperonins
John M. Archibald* and Andrew J. Roger
Program in Evolutionary
Biology, Canadian Institute for
Advanced Research
Department of Biochemistry
and Molecular Biology
Dalhousie University, Halifax
Nova Scotia, B3H 4H7, Canada
Chaperonins are multi-subunit double-ring complexes that mediate the
folding of nascent or denatured proteins. Gene duplication has been a
potent force in the evolution of chaperonins in Archaea. Here we show
that gene conversion has also been an important factor. We utilized a
novel maximum likehood-based phylogenetic method for scanning DNA
sequence alignments for regions of anomalous phylogenetic signal, such
as those affected by gene conversion. Our results suggest that in
crenarchaeotes, where an ancient gene duplication producing a and b
subunits took place in the common ancestor of the Pyrodictium, Aero-
pyrum, Pyrobaculum and Sulfolobus lineages, multiple independent gene

  

Source: Archibald, John - Department of Biochemistry and Molecular Biology, Dalhousie University

 

Collections: Biology and Medicine