Summary: Erythrocytic Adenosine Monophosphate as an Alternative
Purine Source in Plasmodium falciparum*
Received for publication,June 12, 2008, and in revised form, September 16, 2008 Published, JBC Papers in Press,September 17, 2008, DOI 10.1074/jbc.M804497200
María B. Cassera
, Keith Z. Hazleton
, Paul M. Riegelhaupt§
, Emilio F. Merino¶
, Minkui Luo
, Myles H. Akabas§
,
and Vern L. Schramm1
From the Departments of
Biochemistry and §
Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University,
Bronx, New York 10461 and the ¶
Department of Medical Parasitology, New York University Langone Medical Center,
New York, New York 10010
Plasmodium falciparum is a purine auxotroph, salvaging
purines from erythrocytes for synthesis of RNA and DNA.
Hypoxanthine is the key precursor for purine metabolism in

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

Collections: Biology and Medicine