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Synaptic Structural Modification following Changes in Activity Induced by
 

Summary: Synaptic Structural Modification
following Changes in Activity Induced by
Tetanus Neurotoxin in Cat Abducens
Neurons
DAVID GONZAŽ LEZ-FORERO,1,2
ANGEL M. PASTOR,1
JOSE MARIŽA DELGADO-GARCIŽA,3
ROSA R. DE LA CRUZ,1
AND FRANCISCO J. ALVAREZ2*
1
Departamento de FisiologiŽa y ZoologiŽa, Universidad de Sevilla, 41012 Sevilla, Spain
2
Department of Anatomy and Physiology, Wright State University, Dayton, Ohio 45435
3
DivisioŽn de Neurociencia, Universidad Pablo de Olavide, 41013 Sevilla, Spain
ABSTRACT
A low or a high dose of tetanus neurotoxin (TeNT) injected in the lateral rectus muscle of the
cat causes respectively, functional block of inhibitory synapses only or of both inhibitory and
excitatory synapses simultaneously in abducens neurons (GonzaŽlez-Forero et al. [2003] J. Neu-
rophysiol. 89:1878­1890). As a consequence, neuronal firing activity increases (at low dose) or

  

Source: Alvarez, Francisco J. - Department of Neuroscience, Cell Biology, and Physiology, Wright State University

 

Collections: Biology and Medicine