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LETTER doi:10.1038/nature10772 Extrathymically generated regulatory T cells control
 

Summary: LETTER doi:10.1038/nature10772
Extrathymically generated regulatory T cells control
mucosal TH2 inflammation
Steven Z. Josefowicz1,2
*, Rachel E. Niec1
*, Hye Young Kim3
, Piper Treuting4
, Takatoshi Chinen1,5
, Ye Zheng6
, Dale T. Umetsu3
& Alexander Y. Rudensky1
A balance between pro- and anti-inflammatory mechanisms at
mucosal interfaces, which are sites of constitutive exposure to
microbes and non-microbial foreign substances, allows for efficient
protection against pathogens yet prevents adverse inflammatory
responses associated with allergy, asthma and intestinal inflam-
mation1
. Regulatory T (Treg) cells prevent systemic and tissue-
specific autoimmunity and inflammatory lesions at mucosal inter-
faces. These cells are generated in the thymus (tTreg cells) and in

  

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

 

Collections: Biotechnology