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Modafinil Blocks Reinstatement of Extinguished Opiate-Seeking in Rats: Mediation by a Glutamate Mechanism
 

Summary: Modafinil Blocks Reinstatement of Extinguished
Opiate-Seeking in Rats: Mediation by a Glutamate Mechanism
Pouya Tahsili-Fahadan1
, Gregory V Carr2
, Glenda C Harris3
and Gary Aston-Jones*,1
1
Laboratory of Neuromodulation and Behavior, Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA;
2
Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA, USA; 3
Department of Psychiatry, University of Pennsylvania,
Philadelphia, PA, USA
Opiate addiction is characterized by high rates of relapse even after long periods of abstinence, requiring new relapse-prevention
treatments that do not have abuse potential. Recently, clinical studies suggested that the wake-promoting drug modafinil might decrease
relapse in cocaine addicts. In addition, group II metabotropic glutamate receptors (mGlu2/3R) have been suggested as a new therapeutic
target for drug addiction. Here, we investigated the ability of modafinil to prevent the acute morphine to promote reinstatement of
extinguished preference for morphine, and the involvement of mGlu2/3Rs in this effect. Conditioned place preference (CPP) for
morphine was induced in Sprague­Dawley rats, followed by extinction training. Preference for the morphine-paired side was reinstated
following extinction by a morphine-priming injection. The results of our study showed that modafinil (300 mg/kg, i.p., but not 100 mg/kg)
30 min before the morphine-priming injection blocked reinstatement of extinguished CPP. The anti-reinstatement effect of modafinil was

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collections: Biology and Medicine