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BrainResearch, 336(1985)243-251 243 Funicular Course of Catecholamine Fibers Innervating the Lumbar
 

Summary: BrainResearch, 336(1985)243-251 243
Elsevier
BRE 10792
Funicular Course of Catecholamine Fibers Innervating the Lumbar
Spinal Cord of the Cat
R. T. STEVENS, A. V. APKARIAN and C. J. HODGE, Jr.
Dept. of Neurosurgery, UpstateMedical Center, Syracuse, NY13210 (U.S.A.)
(Accepted September 4th, 1984)
Key words: funicular projections -- catecholaminergic-- bulbospinal
The purpose of this study was to determine the funicular location of descending catecholamine (CA) fibers innervating the lumbar
spinal cord from the dorsolateral pons (DLP). The locations of catecholamine-containing cellbodies which project to the lumbar spi-
nal cord were determined by combining the use of the retrogradely transported fluorescent dye, Evans Blue (EB), with the glyoxylic
acid histofluorescence technique. Lumbar injections of Evans Blue were combined with thoracic lesions of the dorsolateral funiculi
(DLF) or ventrolateral funiculi (VLF) in order to retrogradely label those CA-containing or non-CA-containingcell bodies whose ax-
ons descend within the spared hemispinal cord. By this technique it was determined that descending CA fibers innervating the lumbar
spinalcord of the cat project through both the DLF and the VLF. The nucleus subcoeruleus, the Kolliker-Fuse nucleus and the CA cell
bodies in the area of A5 each contain a significant number of CA-containing cells whose fibers descend both within the DLF and the
VLF, while the nucleus locus coeruleus projects to the lumbar cord primarily through the VLF. Catecholamine cellsof the DLP inner-
vate the lumbar spinal cord bilaterally, although there is an ipsilateral predominance. The CA-containing cells of the DLP which in-
nervate the contralateral spinal cord were shown by ipsilateral or contralateral thoracic hemisection to decussate both above and be-

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine