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A newly discovered protein export machine in malaria parasites

A newly discovered protein export
machine in malaria parasites
Tania F. de Koning-Ward1,2
, Paul R. Gilson1,3
, Justin A. Boddey1
, Melanie Rug1
, Brian J. Smith1
Anthony T. Papenfuss1
, Paul R. Sanders1
, Rachel J. Lundie1
, Alexander G. Maier1
, Alan F. Cowman1
& Brendan S. Crabb1,3
Several hundred malaria parasite proteins are exported beyond an encasing vacuole and into the cytosol of the host
erythrocyte, a process that is central to the virulence and viability of the causative Plasmodium species. The trafficking
machinery responsible for this export is unknown. Here we identify in Plasmodium falciparum a translocon of exported
proteins (PTEX), which is located in the vacuole membrane. The PTEX complex is ATP-powered, and comprises heat shock
protein 101 (HSP101; a ClpA/B-like ATPase from the AAA1 superfamily, of a type commonly associated with protein


Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia


Collections: Biotechnology