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The Transcriptome of the Intraerythrocytic Developmental Cycle
 

Summary: The Transcriptome
of the Intraerythrocytic Developmental Cycle
of Plasmodium falciparum
Zbynek Bozdech1[
, Manuel Llina´s1[
, Brian Lee Pulliam1
, Edith D. Wong1
, Jingchun Zhu2
, Joseph L. DeRisi1*
1 Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America, 2 Department of Biological and
Medical Informatics, University of California, San Francisco, San Francisco, California, United States of America
Plasmodium falciparum is the causative agent of the most burdensome form of human malaria, affecting 200­300
million individuals per year worldwide. The recently sequenced genome of P. falciparum revealed over 5,400 genes, of
which 60% encode proteins of unknown function. Insights into the biochemical function and regulation of these genes
will provide the foundation for future drug and vaccine development efforts toward eradication of this disease. By
analyzing the complete asexual intraerythrocytic developmental cycle (IDC) transcriptome of the HB3 strain of P.
falciparum, we demonstrate that at least 60% of the genome is transcriptionally active during this stage. Our data
demonstrate that this parasite has evolved an extremely specialized mode of transcriptional regulation that produces
a continuous cascade of gene expression, beginning with genes corresponding to general cellular processes, such as
protein synthesis, and ending with Plasmodium-specific functionalities, such as genes involved in erythrocyte invasion.

  

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia
Campbell, A. Malcolm - Biology Department, Davidson College

 

Collections: Biology and Medicine; Biotechnology; Multidisciplinary Databases and Resources