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INTRODUCTION The vertebrate embryo is formed by a series of inductive events

The vertebrate embryo is formed by a series of inductive events
that lead to the formation of different cell types, the formation
of organ rudiments and the elaboration of the body axis. In
Xenopus laevis embryos, mesoderm is initially induced and
crudely patterned in the marginal zone at the blastula stage by
signals from the vegetal hemisphere. During gastrulation,
signals produced by the dorsal mesoderm elaborate full meso-
dermal patterning and induce neural tissue in the overlying
ectoderm (for reviews see Harland, 1994; Kimelman et al.,
1992; Slack, 1994).
Members of the fibroblast growth factor (FGF) family have
potent inducing activities in the Xenopus embryo. Several
FGFs and FGF receptors are expressed during blastula and
gastrula stages (reviewed in Slack and Tannahill, 1992) and
FGFs can induce mesoderm when added to explanted animal
cap ectoderm (Kimelman and Kirschner, 1987; Slack et al.,
1987). The requirement for FGF signaling has also been
demonstrated in vivo by introducing RNA encoding a
dominant negative mutant of the FGF receptor into Xenopus


Source: Amaya, Enrique - Healing Foundation Centre & Developmental Biology, Faculty of Life Sciences, University of Manchester
Kroll, Kristen L. - Department of Developmental Biology, Washington University in St. Louis


Collections: Biology and Medicine