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Cell, Vol. 73, 97-108, April 9, 1993, Copyright 0 1993 by Cell Press Multiple Chromosomal Populations of Topoisomerase II
 

Summary: Cell, Vol. 73, 97-108, April 9, 1993, Copyright 0 1993 by Cell Press
Multiple Chromosomal Populations of Topoisomerase II
Detected In Vivo by Time-Lapse, Three-Dimensional
Wide-Field Microscopy
Jason Ft. Swedlow, John W. Sedat,
and David A. Agard
Howard Hughes Medical Institute
Graduate Group in Biophysics
and the Department of Biochemistry and Biophysics
University of California, San Francisco
San Francisco, California 94143-0448
Summary
The localization of topoisomerase II (top0 II) in vlvo
was studied by recording time-lapse, three-dimen-
sional data sets of living Drosophila melanogaster em-
bryos injected with rhodamine-labeled topo II. These
images show that topo II Is concentrated at specific
sites within the interphase nucleus and that this local-
ization is temporally regulated. The enzyme is not re-
stricted to a central chromosome axis, but is distrib-

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collections: Biotechnology; Biology and Medicine