| | |
Summary: Journal of Chromatography A, 1041 (2004) 171180
Determination of pharmaceutical compounds in surface- and
ground-water samples by solid-phase extraction and high-performance
liquid chromatographyelectrospray ionization mass spectrometry
Jeffery D. Cahilla, Edward T. Furlonga,, Mark R. Burkhardta, Dana Kolpina,
Larry G. Andersonb
a National Water Quality Laboratory, US Geological Survey, P.O. Box 25046, MS 407, Denver Federal Center, Denver, CO 80225-0046, USA
b Department of Chemistry, University of Colorado at Denver, P.O. Box 173364, Denver, CO 80217-3364, USA
Received 18 July 2003; received in revised form 26 March 2004; accepted 8 April 2004
Available online 20 May 2004
Abstract
Commonly used prescription and over-the-counter pharmaceuticals are possibly present in surface- and ground-water samples at am-
bient concentrations less than 1 g/L. In this report, the performance characteristics of a combined solid-phase extraction isolation and
high-performance liquid chromatographyelectrospray ionization mass spectrometry (HPLCESI-MS) analytical procedure for routine deter-
mination of the presence and concentration of human-health pharmaceuticals are described. This method was developed and used in a recent
national reconnaissance of pharmaceuticals in USA surface waters. The selection of pharmaceuticals evaluated for this method was based on us-
age estimates, resulting in a method that contains compounds from diverse chemical classes, which presents challenges and compromises when
applied as a single routine analysis. The method performed well for the majority of the 22 pharmaceuticals evaluated, with recoveries greater
than 60% for 12 pharmaceuticals. The recoveries of angiotensin-converting enzyme inhibitors, a histamine (H2) receptor antagonist, and antihy-
poglycemic compound classes were less than 50%, but were retained in the method to provide information describing the potential presence of
|
