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Leading Edge Cell 141, May 28, 2010 2010 Elsevier Inc. 757
 

Summary: Leading Edge
Review
Cell 141, May 28, 2010 2010 Elsevier Inc. 757
Introduction
Most animal cells display obvious polarity, indicating the
presence of molecular asymmetries. The general steps of
cell polarity, including its establishment and transduction, are
common irrespective of cell type or organism: a polarity cue,
regulation of the cytoskeleton, dedicated polarity proteins,
and transduction of polarity information. The initial steps of
polarity have mechanistic parallels in different cell types, and
PAR proteins exemplify this conservation. Identi ed through
seminal work from Ken Kemphues and colleagues in the C.
elegans zygote (Kemphues et al., 1988; Suzuki and Ohno,
2006), PAR proteins are conserved and dedicated regulators
of polarity in animal cells. Of particular importance are PAR-3,
PAR-6, and aPKC (atypical protein kinase C), which form an
asymmetrically localized complex in many polarized cells
(Suzuki and Ohno, 2006). Although initial work in different
organisms suggested a simple view of obligate interactions

  

Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

 

Collections: Biology and Medicine