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How prevalent is functional alternative splicing in the human genome?q

Summary: How prevalent is functional alternative splicing in the
human genome?q
Rotem Sorek1,2
, Ron Shamir3
and Gil Ast1
Department of Human Genetics, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
Compugen, 72 Pinchas Rosen Street, Tel Aviv 69512, Israel
School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel
Comparative analyses of ESTs and cDNAs with genomic
DNA predict a high frequency of alternative splicing in
human genes. However, there is an ongoing debate as
to how many of these predicted splice variants are func-
tional and how many are the result of aberrant splicing
(or `noise'). To address this question, we compared
alternatively spliced cassette exons that are conserved
between human and mouse with EST-predicted cas-
sette exons that are not conserved in the mouse gen-


Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University
Lycan, Deborah E. - Department of Biology, Lewis and Clark College
Sorek, Rotem - Department of Molecular Genetics, Weizmann Institute of Science


Collections: Biology and Medicine