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How prevalent is functional alternative splicing in the human genome?q
 

Summary: How prevalent is functional alternative splicing in the
human genome?q
Rotem Sorek1,2
, Ron Shamir3
and Gil Ast1
1
Department of Human Genetics, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
2
Compugen, 72 Pinchas Rosen Street, Tel Aviv 69512, Israel
3
School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel
Comparative analyses of ESTs and cDNAs with genomic
DNA predict a high frequency of alternative splicing in
human genes. However, there is an ongoing debate as
to how many of these predicted splice variants are func-
tional and how many are the result of aberrant splicing
(or `noise'). To address this question, we compared
alternatively spliced cassette exons that are conserved
between human and mouse with EST-predicted cas-
sette exons that are not conserved in the mouse gen-

  

Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University
Lycan, Deborah E. - Department of Biology, Lewis and Clark College
Sorek, Rotem - Department of Molecular Genetics, Weizmann Institute of Science

 

Collections: Biology and Medicine