Summary: As we find out more about gene regulatory networks, it is not
necessary to assume random topologies and regulatory functions
It is still interesting to see how successful an ON/OFF framework and
Boolean logic can be (as opposed to chemical kinetics-based
Example: Boolean modeling of the segment polarity gene network
synchronous: R. Albert, H. G. Othmer, Journ. Theor. Biol. 223, 1 (2003)
asynchronous: M. Chaves, R. Albert, E. Sontag Journ. Theor. Bio. 235, 431
continuous- Boolean hybrid: M. Chaves, E. Sontag, R. Albert, IEE Proc.
Systems Biology (in print).
Drosophila segmentation is governed by a
cascade of genes
The role of the segment polarity genes
ˇ The segment polarity genes are initiated by the pair-rule genes