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Hypothetical signaling machines in the PSD. (1) NMDA receptor, CaMKII, PSD-95, and SynGAP. (2) mGluR links to the IP3 receptor and to the NMDA receptor complex via a scaffold assembled from Homer and Shank.
 

Summary: Hypothetical signaling machines in the PSD. (1) NMDA receptor, CaMKII, PSD-95, and SynGAP. (2) mGluR
links to the IP3 receptor and to the NMDA receptor complex via a scaffold assembled from Homer and Shank.
Monday, November 22, 2010
LTP is associated with an increase in
AMPA-receptor conductance
Benke et al Nature 393, 793 - 797
Monday, November 22, 2010
Characterisation of silent synapses. A lower failure rate is observed at depolarised
potentials (holding potential of +60 mV; top left) when both NMDARs and AMPARs
contribute to synaptic transmission, than at hyperpolarised potentials (65 mV; top
centre) when only AMPARs mediate transmission (averaged EPSCs for both
conditions, top right; EPSC amplitude vs. time for entire experiment, bottom left;
amplitude histogram for the two holding potentials, bottom right; Liao et al. (1995).
Monday, November 22, 2010
Fig. 1. Electrophysiological characterisation of silent synapses. (A) A lower failure rate is observed at depolarised potentials (holding potential
of +60 mV; top left) when both NMDARs and AMPARs contribute to synaptic transmission, than at hyperpolarised potentials ( 65 mV; top
centre) when only AMPARs mediate transmission (averaged EPSCs for both conditions, top right; EPSC amplitude vs. time for entire experiment,
bottom left; amplitude histogram for the two holding potentials, bottom right; reprinted from Liao et al. (1995), http://www.nature.com/). (B)
Example of an experiment in which no synaptic response was observed at a hyperpolarised potential ( 60 mV), but NMDAR-mediated responses
were observed at a depolarised potential (+30 mV; EPSC amplitude vs. time for entire experiment, top panel; examples of consecutive EPSCs

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collections: Biology and Medicine