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Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

Summary: Review
Regulation of Neurotransmitter Release by Metabotropic
Glutamate Receptors
Jayne Cartmell and Darryle D. Schoepp
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, U.S.A.
Abstract: The G protein-coupled metabotropic gluta-
mate (mGlu) receptors are differentially localized at vari-
ous synapses throughout the brain. Depending on the re-
ceptor subtype, they appear to be localized at presynaptic
and/or postsynaptic sites, including glial as well as neuronal
elements. The heterogeneous distribution of these recep-
tors on glutamate and nonglutamate neurons/cells thus al-
lows modulation of synaptic transmission by a number of
different mechanisms. Electrophysiological studies have
demonstrated that the activation of mGlu receptors can
modulate the activity of Ca2
or K channels, or interfere
with release processes downstream of Ca2
entry, and
consequently regulate neuronal synaptic activity. Such


Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago


Collections: Biology and Medicine