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A High Through-Put Reverse Genetic Screen Identifies Two Genes Involved in Remote Memory in Mice
 

Summary: A High Through-Put Reverse Genetic Screen Identifies
Two Genes Involved in Remote Memory in Mice
Anna Matynia1,2
, Stephan G. Anagnostaras1,2
, Brian J. Wiltgen3
, Maress Lacuesta1,2
, Michael S.
Fanselow3
, Alcino J. Silva1,2,3
*
1 Department of Neurobiology, University of California Los Angeles, Los Angeles, California, United States of America, 2 Department of Psychiatry, University of California
Los Angeles, Los Angeles, California, United States of America, 3 Department of Psychology, University of California Los Angeles, Los Angeles, California, United States of
America
Abstract
Previous studies have revealed that the initial stages of memory formation require several genes involved in synaptic,
transcriptional and translational mechanisms. In contrast, very little is known about the molecular and cellular mechanisms
underlying later stages of memory, including remote memory (i.e. 7-day memory). To identify genes required for remote
memory, we screened randomly selected mouse strains harboring known mutations. In our primary reverse genetic screen,
we identified 4 putative remote memory mutant strains out of a total of 54 lines analyzed. Additionally, we found 11 other
mutant strains with other abnormal profiles. Secondary screens confirmed that mutations of integrin b2 (Itgb2) and steryl-O-

  

Source: Anagnostaras, Stephan - Neurosciences Program & Department of Psychology, University of California at San Diego
Silva, Alcino - Department of Neurobiology, University of California at Los Angeles

 

Collections: Biology and Medicine