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Copyright 2002 by Lipid Research, Inc. This article is available online at http://www.jlr.org Journal of Lipid Research Volume 43, 2002 1899
 

Summary: Copyright 2002 by Lipid Research, Inc.
This article is available online at http://www.jlr.org Journal of Lipid Research Volume 43, 2002 1899
Relationship between stearoyl-CoA desaturase activity
and plasma triglycerides in human and
mouse hypertriglyceridemia
Alan D. Attie,1,* Ronald M. Krauss, Mark P. Gray-Keller,*, Alison Brownlie, Makoto Miyazaki,*
John J. Kastelein,** Aldons J. Lusis, Anton F. H. Stalenhoef, Jonathan P. Stoehr,*
Michael R. Hayden,,*** and James M. Ntambi*,
Department of Biochemistry,* University of Wisconsin-Madison, Madison, WI; Lawrence Berkeley National
Laboratory, University of California-Berkeley, Berkeley, CA; Xenon Genetics, Inc., Burnably, B.C., Canada;
Academic Medical Center,** Amsterdam, The Netherlands; Department of Medicine, UCLA School of
Medicine, Los Angeles, CA; University Medical Center Nijmegen, Nijmegen, The Netherlands; Center for
Molecular and Department of Medical Genetics,*** University of British Columbia, Vancouver, BC, Canada;
and Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI
Abstract Stearoyl-CoA desaturase (SCD) is expressed at
high levels in several human tissues and is required for the
biosynthesis of oleate (18:1) and palmitoleate (16:1). These
monounsaturated fatty acids are the major components of
phospholipids, triglycerides, wax esters, and cholesterol es-
ters. Mice with a targeted disruption of the SCD1 gene have

  

Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison

 

Collections: Biology and Medicine