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Structure, Vol. 10, 12351248, September, 2002, 2002 Elsevier Science Ltd. All rights reserved. PII S0969-2126(02)00838-9 Comparison of In Vivo Selection
 

Summary: Structure, Vol. 10, 1235­1248, September, 2002, 2002 Elsevier Science Ltd. All rights reserved. PII S0969-2126(02)00838-9
Comparison of In Vivo Selection
and Rational Design
of Heterodimeric Coiled Coils
One of the oligomerization domains used commonly
in protein design is the -helical coiled coil [3­6]. Coiled
coils consist of two or more helices that wrap around
one another in a left-handed supercoil. Coiled-coil se-
quences are characterized by a repeat of seven amino
Katja M. Arndt,1,2,4
Joelle N. Pelletier,2,5
Kristian M. Mu¨ ller,1,4
Andreas Plu¨ ckthun,2,3
and Tom Alber1,3
1
Department of Molecular and Cell Biology
University of California, Berkeley
Berkeley, California 94720 acids, denoted a­g (Figure 1A). Most of the residues at
positions a and d are hydrophobic, forming a character-2
Biochemisches Institut

  

Source: Arndt, Katja - Institut für Biologie III, Albert-Ludwigs-Universität Freiburg
Müller, Kristian - Institut für Biologie III, Albert-Ludwigs-Universität Freiburg

 

Collections: Biology and Medicine; Biotechnology