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Maximizing Chemical Diversity of Fungal Metabolites: Biogenetically Related Heptaketides of the Endolichenic Fungus Corynespora sp.1
 

Summary: Maximizing Chemical Diversity of Fungal Metabolites: Biogenetically Related Heptaketides of
the Endolichenic Fungus Corynespora sp.1
E. M. Kithsiri Wijeratne,
Bharat P. Bashyal,
Malkanthi K. Gunatilaka,
A. Elizabeth Arnold,
and A. A. Leslie Gunatilaka*,
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences,
UniVersity of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706-6800, and DiVision of Plant Pathology and Microbiology, School of Plant
Sciences, College of Agriculture and Life Sciences, UniVersity of Arizona, Tucson, Arizona 85721-0036
ReceiVed NoVember 4, 2009
In an attempt to explore the biosynthetic potential of the endolichenic fungus Corynespora sp. BA-10763, its metabolite
profiles under several culture conditions were investigated. When cultured in potato dextrose agar, it produced three
new heptaketides, 9-O-methylscytalol A (1), 7-desmethylherbarin (2), and 8-hydroxyherbarin (3), together with
biogenetically related metabolites scytalol A (4), 8-O-methylfusarubin (5), scorpinone (6), and 8-O-methylbostrycoidin
(7), which are new to this organism, and herbarin (8), a metabolite previously encountered in this fungal strain. The use
of malt extract agar as the culture medium led to the isolation of 6, 8, 1-hydroxydehydroherbarin (9), and
1-methoxydehydroherbarin (10), which was found to be an artifact formed during the extraction of the culture medium
with methanol. The structures of all new compounds were determined by interpretation of their spectroscopic data and
chemical interconversions.

  

Source: Arnold, A. Elizabeth - School of Plant Sciences, University of Arizona

 

Collections: Biology and Medicine