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AGEING NEUROREPORT 0959-4965 & Lippincott Williams & Wilkins Vol 12 No 15 29 October 2001 3321
 

Summary: AGEING NEUROREPORT
0959-4965 & Lippincott Williams & Wilkins Vol 12 No 15 29 October 2001 3321
Requirement of Notch in adulthood for
neurological function and longevity
Asaf Presente,1
Andrew Andres1
and Jeffrey S. Nye1,2,CA
Departments of 1
Molecular Pharmacology and Biological Chemistry, and 2
Pediatrics, Northwestern University School of
Medicine, 303 E. Chicago Ave. MC S215, Chicago, IL 60611 USA
CA,1
Corresponding Author. Current address: CNS Genomics Discovery Research, Pharmacia Corporation, 301 Henrietta
Street, Kalamazoo, MC 49007, USA
Received 25 June 2001; accepted 8 August 2001
Although Notch proteins rely upon presenilins for activation
and can modulate neuritic architecture, their role in aging
adults and Alzheimer's disease is unknown. Here we examine
Drosophila in which Notch function was selectively diminished
in adulthood. An outcrossing strategy was employed to reduce

  

Source: Andres, Andrew - School of Life Sciences, University of Nevada at Las Vegas

 

Collections: Biology and Medicine