| | |
Summary: Elucidating the genetic architecture of familial
schizophrenia using rare copy number variant
and linkage scans
Bin Xua,b,1
, Abigail Woodroffec,1
, Laura Rodriguez-Murilloa
, J. Louw Roosd
, Elizabeth J. van Rensburge
,
Gonc¸alo R. Abecasisf
, Joseph A. Gogosb,g,2
, and Maria Karayiorgoua,2
Departments of aPsychiatry, bPhysiology and Cellular Biophysics, and gNeuroscience, Columbia University Medical Center, New York, NY 10032; Departments
of cEpidemiology and fBiostatistics, University of Michigan, Ann Arbor, MI 48109; dDepartment of Psychiatry, Weskoppies Hospital, Pretoria, Republic of
South Africa 0001; and eDepartment of Genetics, University of Pretoria, Pretoria, Republic of South Africa 0001
Communicated by David E. Housman, Massachusetts Institute of Technology, Cambridge, MA, August 8, 2009 (received for review June 16, 2009)
To elucidate the genetic architecture of familial schizophrenia we
combine linkage analysis with studies of fine-level chromosomal
variation in families recruited from the Afrikaner population in
South Africa. We demonstrate that individually rare inherited copy
|
