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Scaling of number, size, and metabolic rate of cells with body size in mammals
 

Summary: Scaling of number, size, and metabolic rate of cells
with body size in mammals
Van M. Savage*§¶
, Andrew P. Allen , James H. Brown¶
**, James F. Gillooly
, Alexander B. Herman§
,
William H. Woodruff§
, and Geoffrey B. West§
*Department of Systems Biology, Harvard Medical School, Boston, MA 02115; Bauer Laboratory, Harvard University, 7 Divinity Avenue,
Cambridge, MA 02138; Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501; §Los Alamos National Laboratory, Los Alamos,
NM 87545; National Center for Ecological Analysis and Synthesis, Santa Barbara, CA 93101; **Department of Biology, University
of New Mexico, Albuquerque, NM 87131; and Department of Zoology, University of Florida, Gainesville, FL 32611
Contributed by James H. Brown, December 27, 2006 (sent for review November 15, 2006)
The size and metabolic rate of cells affect processes from the molec-
ular to the organismal level. We present a quantitative, theoretical
framework for studying relationships among cell volume, cellular
metabolic rate, body size, and whole-organism metabolic rate that
helps reveal the feedback between these levels of organization. We
use this framework to show that average cell volume and average

  

Source: Allen, Andrew P. - National Center for Ecological Analysis and Synthesis, University of California at Santa Barbara
Brown, James H. - Department of Biology, University of New Mexico

 

Collections: Environmental Sciences and Ecology