Summary: Journal of Clinical Immunology, Vol. 23, No. 4, July 2003 (C 2003)
Immunoglobulin Deficiencies and Susceptibility to Infection
Among Homozygotes and Heterozygotes for C2 Deficiency
CHESTER A. ALPER,1,2,7
JIANHUA XU,1,2
KATHERINE COSMOPOULOS,1
BRIAN DOLINSKI,1
ROSANNE
STEIN,1
GABRIEL UKO,1,2
CHARLES E. LARSEN,1,3
DEVENDRA P. DUBEY,1
PETER DENSEN,4
LENNART TRUEDSSON,5
GUNNAR STURFELT,6
and ANDERS G. SJ ¨OHOLM5
Accepted: March 14, 2003
About 25% of C2-deficient homozygotes have increased suscep-
tibility to severe bacterial infections. C2-deficient homozygotes
had significantly lower serum levels of IgG2, IgG4, IgD, and

Source: Alper, Chester A. - Immune Disease Institute, Harvard University

Collections: Biology and Medicine