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Journal of Clinical Immunology, Vol. 23, No. 4, July 2003 (C 2003) Immunoglobulin Deficiencies and Susceptibility to Infection
 

Summary: Journal of Clinical Immunology, Vol. 23, No. 4, July 2003 (C 2003)
Immunoglobulin Deficiencies and Susceptibility to Infection
Among Homozygotes and Heterozygotes for C2 Deficiency
CHESTER A. ALPER,1,2,7
JIANHUA XU,1,2
KATHERINE COSMOPOULOS,1
BRIAN DOLINSKI,1
ROSANNE
STEIN,1
GABRIEL UKO,1,2
CHARLES E. LARSEN,1,3
DEVENDRA P. DUBEY,1
PETER DENSEN,4
LENNART TRUEDSSON,5
GUNNAR STURFELT,6
and ANDERS G. SJ šOHOLM5
Accepted: March 14, 2003
About 25% of C2-deficient homozygotes have increased suscep-
tibility to severe bacterial infections. C2-deficient homozygotes
had significantly lower serum levels of IgG2, IgG4, IgD, and

  

Source: Alper, Chester A. - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine