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role in both homeostatic and adaptive processes (see, for example, Abbott and Marder, 2002), synaptic plas-
 

Summary: role in both homeostatic and adaptive processes (see,
for example, Abbott and Marder, 2002), synaptic plas-
ticity, in particular long-term potentiation and depres-
sion (LTP and LTD), has received the most attention
from both experimentalists and modelers. In particular,
associative forms of LTP and LTD, which follow gen-
eral ideas about plasticity annunciated by Hebb and
others (Hebb, 1949), have been the focus of work on
learning and memory in neural circuits. An important
feature of experimentally measured LTP and LTD,
which has been stressed particularly in recent work,
concerns the role of spike timing in its induction.
Results from a wide range of systems (reviewed in Ab-
bott and Nelson, 2000), including rat hippocampal cul-
ture and slice preparations (Levy and Stewart, 1983;
Gustafsson et al., 1987; Debanne et al., 1994; Bi and
0944-2006/03/106/04-365 $ 15.00/0
Introduction
Neural circuits are both highly adaptive and sturdily ro-
bust, attributes that are difficult to reconcile with each

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine