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Summary: Boolean Modeling of Serotonin
mediated Ca2+ Signaling pathway
Gaurav Bhardwaj
IBIOS (CDB)
Calcium Signaling
http://dir.niehs.nih.gov/dirlst/images/fig-putney.jpg
Calcium Signaling in neuroscience
ˇ Ca2+ is key secondary messenger in
neuronal guidance
ˇ Short term responses such as changes in
growth cone guidance, rearrangement of
cytoskeleton, neurotransmitter release
ˇ Long term responses: Gene transcription
leading to terminal differentiation.
Altered Calcium Signaling Effects
Normal Physiological
ˇ Neurotransmitter Release
ˇ Long Term Potentiation
ˇ Long Term Differentiation
Pathophysiological
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