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Am. J. Hum. Genet. 66:629650, 2000 Estimation of Variance Components of Quantitative Traits in Inbred
 

Summary: Am. J. Hum. Genet. 66:629650, 2000
629
Estimation of Variance Components of Quantitative Traits in Inbred
Populations
Mark Abney,1,2
Mary Sara McPeek,2
and Carole Ober1
Departments of 1
Human Genetics and 2
Statistics, University of Chicago, Chicago
Summary
Use of variance-component estimation for mapping of
quantitative-trait loci in humans is a subject of great
current interest. When only trait values, not genotypic
information, are considered, variance-component esti-
mation can also be used to estimate heritability of a
quantitative trait. Inbred pedigrees present special chal-
lenges for variance-component estimation. First, there
are more variance components to be estimated in the
inbred case, even for a relatively simple model including

  

Source: Abney, Mark - Department of Human Genetics, University of Chicago

 

Collections: Computer Technologies and Information Sciences; Biology and Medicine