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Genome Analysis Insights into the connection between cancer and

Summary: Genome Analysis
Insights into the connection between cancer and
alternative splicing
Eddo Kim*
, Amir Goren*
and Gil Ast
Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv 69978, Israel
Computational and experimental evidence has revealed
that cancerous cells express transcript variants that are
abnormally spliced, suggesting that mRNAs are more
frequently alternatively spliced in cancerous tissues than
in normal ones. We show that cancerous tissues exhibit
lower levels of alternative splicing than do normal tis-
sues. Moreover, we found that the distribution of types
of alternative splicing differs between cancerous and
normal tissues. We further show evidence suggesting
that the lower levels of alternative splicing in cancerous
tissues might be a result of disruption of splicing regu-
latory proteins.
Alternative splicing and cancer


Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University


Collections: Biology and Medicine