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Selectional and Mutational Scope of Peptides Sequestering the JunFos Coiled-Coil Domain
 

Summary: Selectional and Mutational Scope of Peptides
Sequestering the Jun­Fos Coiled-Coil Domain
Urs B. Hagemann, Jody M. Mason, Kristian M. Müller
and Katja M. Arndt
Institute for Biology III,
Albert-Ludwigs-University of
Freiburg, Schaenzlestrass 1,
D-79104 Freiburg, Germany
Received 11 December 2007;
received in revised form
7 April 2008;
accepted 11 April 2008
Available online
17 May 2008
The activator protein-1 (AP-1) complex plays a crucial role in numerous
pathways, and its ability to induce tumorigenesis is well documented. Thus,
AP-1 represents an interesting therapeutic target. We selected peptides from
phage display and compared their ability to disrupt the cFos/cJun inter-
action to a previously described in vivo protein-fragment complementa-
tion assay (PCA). A cJun-based library was screened to enrich for peptides

  

Source: Arndt, Katja - Institut für Biologie III, Albert-Ludwigs-Universität Freiburg
Mason, Jody - Department of Biological Sciences, University of Essex

 

Collections: Biology and Medicine; Biotechnology