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Introduction The NF-B/Rel family of transcription factors is composed of

Summary: Introduction
The NF- B/Rel family of transcription factors is composed of
five members: p50 (NF- B1), p52 (NF- B2), p65 (RelA),
RelB and c-Rel. Each member of this family participates in the
formation of homo- or heterodimers that are retained in the
cytoplasm of resting cells by inhibitor-kappa B (I B) proteins
(Ghosh and Karin, 2002). Nuclear translocation of NF- B
dimers is dependent on the phosphorylation, ubiquitination and
degradation of I B proteins, primarily I B , by the I B kinase
(IKK) complex following cell stimulation (Hayden and Ghosh,
2004; Mercurio et al., 2000). Once in the nucleus, NF- B
regulates the transcription of several genes involved in immune
responses, cell proliferation, survival and apoptosis (Ghosh and
Karin, 2002; Karin and Lin, 2002; Richmond, 2002).
It is well recognized that microbial pathogens have evolved
diverse strategies to manipulate the NF- B pathway (Tato and
Hunter, 2002). Inhibition of NF- B activation has the potential
of interfering with the development of antimicrobial immune
responses, thus providing a survival advantage to the infectious
agent. Additionally, activation of NF- B might upregulate


Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia


Collections: Biotechnology