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ACCELERATED COMMUNICATION Di(2-ethylhexyl) phthalate Is a Highly Potent Agonist for the

Di(2-ethylhexyl) phthalate Is a Highly Potent Agonist for the
Human Constitutive Androstane Receptor Splice Variant CAR2
Joshua G. DeKeyser, Michael C. Stagliano, Scott S. Auerbach, K. Sandeep Prabhu,
A. Daniel Jones, and Curtis J. Omiecinski
Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences (J.G.D., K.S.P.,
C.J.O.), and Department of Chemistry (M.C.S), the Pennsylvania State University, University Park, Pennsylvania; Departments of
Biochemistry & Molecular Biology (M.C.S., A.D.J.), and Chemistry (A.D.J.), Michigan State University, East Lansing, Michigan;
and National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
Received November 25, 2008; accepted February 5, 2009
The human constitutive androstane receptor (CAR, CAR1) reg-
ulates the expression of genes involved in xenobiotic metabo-
lism in the liver. The CAR gene uses multiple alternative splicing
events during pre-mRNA processing, thereby enhancing the
CAR transcriptome. Previous reports have identified two prom-
inent human CAR variants, CAR2 and CAR3, that possess four-
and five-amino acid insertions in their ligand binding domains,
respectively. Unlike the constitutively active reference form of


Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University
Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University


Collections: Biology and Medicine