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Neuron, Vol. 21, 581591, September, 1998, Copyright 1998 by Cell Press Novel Anchorage of GluR2/3 to the Postsynaptic

Summary: Neuron, Vol. 21, 581­591, September, 1998, Copyright ©1998 by Cell Press
Novel Anchorage of GluR2/3 to the Postsynaptic
Density by the AMPA Receptor­Binding Protein ABP
A­D) subunits (Hollmann and Heinemann, 1994), medi-
ate fast excitatory transmission, while NMDA receptors,
which are assembled from the NR1 and NR2A-D sub-
S. Srivastava,* P. Osten,* F. S. Vilim,*§ L. Khatri,*
G. Inman,* B. States,* C. Daly,* S. DeSouza,*
R. Abagyan, J. G. Valtschanoff, R. J. Weinberg,
and E. B. Ziff*# units, may provide synaptic modification through their
*Howard Hughes Medical Institute ability to admit Ca2
ions (McBain and Mayer, 1994). In
and Department of Biochemistry one model for synaptic plasticity, functionally "silent"
New York University Medical Center synapses bearing NMDA receptors are activated through
New York, New York 10016 the synaptic insertion or activation of AMPA receptors
and Skirball Institute by an NMDA receptor­dependent mechanism (Maren et
Department of Biochemistry al., 1993; Isaac et al., 1995; Liao et al., 1995; Malenka
New York University Medical Center and Nicoll, 1997). This model implies that the AMPA and
New York, New York 10016 NMDA receptors undergo different forms of processing
and Courant Institute of Mathematics prior to functioning at synapses. Indeed, AMPA recep-


Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego


Collections: Biology and Medicine