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Compensatory endocytosis in bladder umbrella cells occurs through an integrin-regulated and
 

Summary: Compensatory endocytosis in bladder umbrella
cells occurs through an integrin-regulated and
RhoA- and dynamin-dependent pathway
Puneet Khandelwal1
, Wily G Ruiz1
and Gerard Apodaca1,2,
*
1
Department of Medicine, Laboratory of Epithelial Cell Biology and
Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA,
USA and 2
Department of Cell Biology and Physiology, University of
Pittsburgh, Pittsburgh, PA, USA
Compensatory endocytosis (CE) ensures recycling of mem-
brane components and maintenance of plasma membrane
size; however, the mechanisms, regulation, and physio-
logical functions of clathrin-independent modes of CE are
poorly understood. CE was studied in umbrella cells, which
undergo regulated exocytosis of subapical discoidal/
fusiform vesicles (DFV) during bladder filling, and may

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collections: Biology and Medicine