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COBIOT-658; NO OF PAGES 6 Please cite this article in press as: Dougherty MJ, Arnold FH. Directed evolution: new parts and optimized function, Curr Opin Biotechnol (2009), doi:10.1016/j.copbio.2009.08.005
 

Summary: COBIOT-658; NO OF PAGES 6
Please cite this article in press as: Dougherty MJ, Arnold FH. Directed evolution: new parts and optimized function, Curr Opin Biotechnol (2009), doi:10.1016/j.copbio.2009.08.005
Available online at www.sciencedirect.com
Directed evolution: new parts and optimized function
Michael J Dougherty1
and Frances H Arnold1,2
Constructing novel biological systems that function in a robust
and predictable manner requires better methods for
discovering new functional molecules and for optimizing their
assembly in novel biological contexts. By enabling functional
diversification and optimization in the absence of detailed
mechanistic understanding, directed evolution is a powerful
complement to `rational' engineering approaches. Aided by
clever selection schemes, directed evolution has generated
new parts for genetic circuits, cell­cell communication
systems, and non-natural metabolic pathways in bacteria.
Addresses
1
Division of Chemistry & Chemical Engineering, California Institute of
Technology, Pasadena, CA 91125, USA

  

Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology

 

Collections: Chemistry; Biology and Medicine