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BioMed Central Page 1 of 13

Summary: BioMed Central
Page 1 of 13
(page number not for citation purposes)
Molecular Pain
Open AccessMethodology
Spared nerve injury rats exhibit thermal hyperalgesia on an
automated operant dynamic thermal escape Task
Marwan Baliki, Oscar Calvo, Dante R Chialvo and A Vania Apkarian*
Address: Department of Physiology, Northwestern University Medical School, Chicago, IL, 60611, USA
Email: Marwan Baliki - marwanbaliki@hotmail.com; Oscar Calvo - oscar@galiota.uib.es; Dante R Chialvo - dchialvo@ucla.edu; A
Vania Apkarian* - a-apkarian@northwestern.edu
* Corresponding author
Neuropathic PainSpared Nerve InjuryChronic Constriction InjuryAllodyniaPain Behaviorratmouse
Well-established methods are available to measure thermal and mechanical sensitivity in awake
behaving rats. However, they require experimenter manipulations and tend to emphasize reflexive
behaviors. Here we introduce a new behavioral test, with which we examine thermal sensitivity of
rats with neuropathic injury. We contrast thermal hyperalgesia between spared nerve injury and
chronic constriction injury rats. This device is a fully automated thermal sensitivity assessment tool
designed to emphasize integrated learned responses to thermal painful and non-painful stimuli that


Source: Apkarian, A. Vania - Department of Physiology, Northwestern University


Collections: Biology and Medicine