Summary: Nhp6 facilitates Aft1 binding and Ssn6
recruitment, both essential for FRE2
transcriptional activation
George S Fragiadakis1,2
, Dimitris
Tzamarias1,3
and Despina Alexandraki1,2,
*
1
Institute of Molecular Biology and Biotechnology-FORTH, University
of Crete, Vassilika Vouton, Heraklion, Crete, Greece, 2
Department
of Biology, University of Crete, Greece and 3
School of Science
and Technology, Hellenic Open University, Greece
We found Nhp6a/b yeast HMG-box chromatin-associated
architectural factors and Ssn6 (Cyc8) corepressor to be
crucial transcriptional coactivators of FRE2 gene. FRE2
encoding a plasma membrane ferric reductase is induced
by the iron-responsive, DNA-binding, transcriptional acti-

Source: Alexandraki, Despina - Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, Hellas

Collections: Biology and Medicine; Biotechnology