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Copyright 2004 by the Genetics Society of America DOI: 10.1534/genetics.103.023218

Summary: Copyright 2004 by the Genetics Society of America
DOI: 10.1534/genetics.103.023218
Quantitative Trait Loci Affecting Life Span in Replicated Populations of
Drosophila melanogaster. I. Composite Interval Mapping
Scott N. Forbes,1
Robert K. Valenzuela, Paul Keim and Philip M. Service2
Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86011
Manuscript received October 15, 2003
Accepted for publication June 9, 2004
Composite interval mapping was used to identify life-span QTL in F2 progeny of three crosses between
different pairs of inbred lines. Each inbred line was derived from a different outbred population that had
undergone long-term selection for either long or short life span. Microsatellite loci were used as genetic
markers, and confidence intervals for QTL location were estimated by bootstrapping. A minimum of 10
QTL were detected, nine of which were located on the two major autosomes. Five QTL were present in
at least two crosses and five were present in both sexes. Observation of the same QTL in more than one
cross was consistent with the hypothesis that genetic variation for life span is maintained by balancing
selection. For all QTL except one, allelic effects were in the direction predicted on the basis of outbred
source population. Alleles that conferred longer life were always at least partially dominant.
DROSOPHILA melanogaster has been a model or- undertake such studies. Identification of life-span genes


Source: Allan, Gery - Department of Biological Sciences, Northern Arizona University


Collections: Biology and Medicine; Environmental Sciences and Ecology