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Summary: Neuron
Article
A Coordinated Local Translational Control Point
at the Synapse Involving Relief from Silencing
and MOV10 Degradation
Sourav Banerjee,1 Pierre Neveu,1,2 and Kenneth S. Kosik1,*
1Neuroscience Research Institute and Department of Cellular Molecular and Developmental Biology
2Kavli Institute for Theoretical Physics
University of California, Santa Barbara, Santa Barbara, CA 93106, USA
*Correspondence: kosik@lifesci.ucsb.edu
DOI 10.1016/j.neuron.2009.11.023
SUMMARY
Persistent changes in synaptic strength are locally
regulated by both protein degradation and synthesis;
however, the coordination of these opposing limbs
is poorly understood. Here, we found that the RISC
protein MOV10 was present at synapses and was
rapidly degraded by the proteasome in an NMDA-
receptor-mediated activity-dependent manner. We
designed a translational trap to capture those mRNAs
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