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IMMUNOBIOLOGY CD2 engagement induces dendritic cell activation: implications for

CD2 engagement induces dendritic cell activation: implications for
immune surveillance and T-cell activation
Keith Crawford, Aleksandra Stark, Betsy Kitchens, Kerry Sternheim, Vassilios Pantazopoulos, Ellen Triantafellow,
Zhigang Wang, Baldev Vasir, Charles E. Larsen, Dana Gabuzda, Ellis Reinherz, and Chester A. Alper
We have shown previously that primary
dendritic cells and monocytes express
equal levels of CD14 but are distinguish-
able by the presence of CD2 on dendritic
cells. CD2 is known to mediate the activa-
tion of T and natural killer (NK) cells
through its interaction with CD58. CD2
epitopes recognized by anti-T111, -T112,
and -T113 monoclonal antibodies (mAbs)
are present on dendritic cells. Here we
show that CD2 engagement significantly
increases class II, costimulatory (CD40,
CD80, CD86), adhesion (CD54, CD58), and
CCR7 molecule expression on primary
dendritic cells. Conversely, minimal or no


Source: Alper, Chester A. - Immune Disease Institute, Harvard University


Collections: Biology and Medicine