Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Nature GeNetics VOLUME 42 | NUMBER 6 | JUNE 2010 495 Agenome-wideassociationscanof~6.6milliongenotypedor
 

Summary: Nature GeNetics VOLUME 42 | NUMBER 6 | JUNE 2010 495
Agenome-wideassociationscanof~6.6milliongenotypedor
imputedvariantsin882Sardinianindividualswithmultiple
sclerosis(cases)and872controlssuggestedassociationofCBLB
genevariantswithdisease,whichwasconfirmedin1,775
casesand2,005controls(rs9657904,overallP=1.6010-10,
OR=1.40).CBLBencodesanegativeregulatorofadaptive
immuneresponses,andmicelackingtheorthologareprone
toexperimentalautoimmuneencephalomyelitis,theanimal
modelofmultiplesclerosis.
Multiple sclerosis (MS) is a multifactorial neuroinflammatory and
autoimmune disorder. A primary cause of disability in young adults,
it results from interactions between unknown environmental factors
and alleles of many susceptibility loci across the genome. Recent inves-
tigations of the genetics of MS have resulted in important advances,
driven largely by completion of the first genome-wide association
studies (GWAS)13. Thus far, the major GWAS findings have come
from analyses of northern European populations and derived popula-
tions in which MS is particularly common. Although MS has a low
incidence in geographically neighboring populations, it is common in

  

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan

 

Collections: Biology and Medicine; Mathematics