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RESEARCH ARTICLES Arabidopsis Relatives of the Human Lysine-Specific

Arabidopsis Relatives of the Human Lysine-Specific
Demethylase1 Repress the Expression of FWA and
FLOWERING LOCUS C and Thus Promote the
Floral Transition W
Danhua Jiang,a,1 Wannian Yang,a,b,1 Yuehui He,a,b,2 and Richard M. Amasinoc
a Department of Biological Sciences, National University of Singapore, Singapore 117543, Republic of Singapore
b Temasek Life Sciences Laboratory, Singapore 117604, Republic of Singapore
c Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706
The timing of the developmental transition to flowering is critical to reproductive success in plants. Here, we show that
Arabidopsis thaliana homologs of human Lysine-Specific Demethylase1 (LSD1; a histone H3-Lys 4 demethylase) reduce the
levels of histone H3-Lys 4 methylation in chromatin of the floral repressor FLOWERING LOCUS C (FLC) and the sporophytically
silenced floral repressor FWA. Two of the homologs, LSD1-LIKE1 (LDL1) and LSD1-LIKE2 (LDL2), act in partial redundancy with
FLOWERING LOCUS D (FLD; an additional homolog of LSD1) to repress FLC expression. However, LDL1 and LDL2 appear to act
independently of FLD in the silencing of FWA, indicating that there is target gene specialization within this histone demethylase
family. Loss of function of LDL1 and LDL2 affects DNA methylation on FWA, whereas FLC repression does not appear to involve
DNA methylation; thus, members of the LDL family can participate in a range of silencing mechanisms.
The developmental transition from a vegetative to a reproductive
phase (i.e., flowering) is perhaps the most critical event in the plant


Source: Amasino, Richard M. - Department of Biochemistry, University of Wisconsin at Madison


Collections: Biology and Medicine