Summary: USING INDENTATION AND INTRA-VASCULAR
ULTRASOUND TO MEASURE ARTERIAL RESPONSE
P.M. Anderson, E.N. Glaser, A.I. Veress#, G.M. Pharr+, D.G. Vince§, J.F. Cornhill§, and E.E.
Materials Science and Engineering, Ohio State University, 2041 College Rd., Columbus, OH
Biomedical Engineering, Ohio State University, Columbus, OH 43210-1002.
#Medical Imaging Research Lab, University of Utah, Salt Lake City, UT 84108-1218.
+Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831-6116.
§Biomedical Engineering, The Cleveland Clinic, Cleveland, OH 44195-0001.
Two alternatives to standard tensile testing of arteries are discussed. The first involves
inflation of arteries and simultaneous measurement of radial displacement with intra-vascular
ultrasound (IVUS). The second involves the measurement of load versus displacement during
micro-indentation of the intimal surface. The IVUS technique is used to study the nonlinear
stiffening of porcine coronaries during inflation and, ultimately, it may provide a method to
determine mechanical properties in vivo. Processing of the IVUS data relies on accurate
determination of the luminal/intimal and medial/advential boundaries during inflation. The
microindentation technique is used to study the effect of loading rate on tissue stiffness,
recovery, and internal dissipation. Ultimately, this technique may provide a method to measure