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Brain Research, 204 (1981)415-420 415 Elsevier/North-Holland BiomedicalPress
 

Summary: Brain Research, 204 (1981)415-420 415
Elsevier/North-Holland BiomedicalPress
Locus coeruleus modulation of dorsal horn unit responses to cutaneous
stimulation
C. J. HODGE, JR., A. V. APKARIAN, R. STEVENS, G. VOGELSANG and H. J. WISNICKI
Department of Neurosurgery, Upstate Medical Center, Syracuse, N.Y. 13210 (U.S.A.)
(Accepted August 14th, 1980)
Key words: locuscoeruleus -- dorsal horn cells-- noradrenaline
Neurons of the locus coeruleus (LC) and subcoeruleus area have axons which
terminate in the spinal cord1,19'A5,2,26. Terminals of at least some of these neurons
contain noradrenalinel,11, is. The presence of dense CA terminal concentrations in the
apex of the dorsal hornlZ,19, alterations in dorsal horn interneuron responses to
cutaneous stimulation following intravenous L-DOPA injection4,16 or iontophoretic
application of noradrenaline (NA)la, 25, changes in pain response thresholds after des-
tructive lesions of LC 7, and the apparent interaction of stimulation-produced and nar-
cotic analgesic activity with functioning catecholaminergic systems2,8 all suggest that
noradrenergic brain stem nuclei are able to alter sensory transmission at the dorsal
horn level.
In the experiments briefly described here, the functional effects of the LC projec-
tion to the lumbar spinal dorsal horn were directly evaluated by determining the chan-

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine