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Traffic 2001 2: 149159 Munksgaard International Publishers
 

Summary: Traffic 2001 2: 149159
Munksgaard International Publishers
Review
Endocytic Traffic in Polarized Epithelial Cells: Role of
the Actin and Microtubule Cytoskeleton
Gerard Apodaca
Renal-Electrolyte Division of the Department of Medicine,
Laboratory of Epithelial Biology, and Department of Cell
Biology and Physiology, University of Pittsburgh, Pittsburgh,
PA 15261, USA
gla6@pitt.edu
The cytoskeleton is required for multiple cellular events
including endocytosis and the transfer of cargo within
the endocytic system. Polarized epithelial cells are capa-
ble of endocytosis at either of their distinct apical or
basolateral plasma membrane domains. Actin plays a
role in internalization at both cell surfaces. Microtubules
and actin are required for efficient transcytosis and deliv-
ery of proteins to late endosomes and lysosomes. Micro-
tubules are also important in apical recycling pathways

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collections: Biology and Medicine