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Nanoscale Cues and Astrocyte Responses in Neural System Regenerative Medicine Volkan M. Tiryaki, Virginia M. Ayres, Adeel, A. Khan, Dexter A. Flowers
 

Summary: Nanoscale Cues and Astrocyte Responses in Neural System Regenerative Medicine
Volkan M. Tiryaki, Virginia M. Ayres, Adeel, A. Khan, Dexter A. Flowers
Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, United States
Abstract- The goal of regenerative medicine is to create a scaffold which is biomimetic for the native attachment
environment of a given cell group, which, prompted by nanoscale cues, re-colonizes the scaffold. In the present
investigation, astrocyte responses are correlated with the mechanical, topographical and biochemical cues of a prosthetic
environment.
Recent efforts in the field of regenerative medicine have
yielded impressive successes [1]. The basis of regenerative
medicine is to create a scaffold which is biomimetic for the
native extracellular matrix (ECM) of a given tissue and to
then expose it to a desired cell population, which may contain
adult, embryonic or pluripotent stem cells. If the scaffold has
the correct nanoscale cues, the cells will naturally re-colonize
the prosthetic ECM matrix and resume normal functions.
Fundamental understanding is still needed to design scaffolds
with appropriate mechanical, topographical and biochemical
cues for particular cell classes. Understanding the nature of
the physical interactions of cells within these biomimetic
structures and deriving information that would correlate

  

Source: Ayres, Virginia - Department of Electrical and Computer Engineering, Michigan State University

 

Collections: Materials Science; Biology and Medicine