Summary: Cell, Vol. 120, 163­166, January 28, 2005, Copyright ©2005 by Elsevier Inc. DOI 10.1016/j.cell.2005.01.002
Meeting ReviewThe Spanish Connection:
Transcription and mRNA
Processing Get Even Closer
place before elongation can fully proceed (Figure 1A).
At early elongation, the C-terminal domain (CTD) of the
Pol II large subunit (Rpb1) becomes phosphorylated on
serine 5 positions within its characteristic heptad re-
peats. Ser5 phosphorylation at CTD recruits the mRNA
Manuel Ares, Jr.1,
* and Nick J. Proudfoot2,
*
1
Department of Molecular Cell
and Developmental Biology
University of California, Santa Cruz
Santa Cruz, California 95064
2
Sir William Dunn School of Pathology capping complex, which adds a cap to the initial nascent
transcript. Ser5 phosphorylation is also associated withUniversity of Oxford

Source: Ares Jr., Manny - Department of Molecular, Cell, and Developmental Biology, University of California at Santa Cruz

Collections: Biology and Medicine